文章摘要
高颐雄;赵 勤;谭 信;张 坚.n-3多不饱和脂肪酸抑制骨骼肌蛋白异常分解的研究进展[J].中国食品学报,2019,19(8):312-317
n-3多不饱和脂肪酸抑制骨骼肌蛋白异常分解的研究进展
  
DOI:
中文关键词: 胰岛素/Akt信号通路  n-3多不饱和脂肪酸  骨骼肌细胞  蛋白分解
英文关键词: insulin / Akt signaling pathway  n-3 polyunsaturated fatty acid  skeletal muscle cell  proteolysis
基金项目:国家自然科学基金项目(81602857)
作者单位
高颐雄;赵 勤;谭 信;张 坚 中国疾病预防控制中心营养与健康所北京100050北京理工大学生命学院北京100081 
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中文摘要:
      胰岛素/Akt信号通路受阻所致的骨骼肌细胞蛋白异常分解,可能是骨骼肌萎缩发生的重要原因。不同n-3多不饱和脂肪酸在骨骼肌细胞内、外作用于胰岛素/Akt信号通路上的多个位点,均有助于维持通路的正常运作。其中,植物来源n-3多不饱和脂肪酸ALA能通过活化胰岛β细胞胞膜的GPR40直接促进胰岛素分泌;海鱼来源n-3多不饱和脂肪酸EPA与DHA能有效维持骨骼肌细胞内Akt活性并增加胰岛素敏感性。本文通过对相关文献的归纳总结,阐释n-3多不饱和脂肪酸基于胰岛素/Akt信号通路抑制骨骼肌细胞蛋白异常分解的机制,为通过膳食手段干预骨骼肌萎缩提供新的思路。
英文摘要:
      The probable reason of skeletal muscle atrophy would be insulin / Akt signaling pathway block-mediated abnormity of protein metabolism in skeletal muscle cell. n-3 polyunsaturated fatty acids(n-3 PUFA) can act on various sites inside and outside skeletal muscle cells to maintain the pathway. ALA is a plant-derived n-3 PUFA, which is more effective on direct stimulation of secretion of insulin via GPR40 on the membrane of pancreatic beta cell. EPA and DHA are marine fish-derived n-3 polyunsaturated fatty acids(n-3 PUFA), which can maintain the activation of Akt pathway in skeletal muscle cell and have shown beneficial effects on insulin sensitivity. Ralated researches were reviewed to understand the role of n-3 PUFA in prevention of abnormal proteolysis in skeletal muscle cell and to previde new ideas for the intervention of skeletal muscle atrophy by dietary nutrients.
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