文章摘要
袁媛;刘黄友;闫海洋;孙冶.食源性柚皮苷抗氧化性及其对呋喃所致小鼠肝肾损伤的保护作用[J].中国食品学报,2019,19(9):13-20
食源性柚皮苷抗氧化性及其对呋喃所致小鼠肝肾损伤的保护作用
Antioxidant Activity of Naringin and Its Protective Effects on Furan-induced Liver and Kidney Damage
  
DOI:
中文关键词: 柚皮苷  呋喃  氧化损伤  肝肾损伤  保护作用
英文关键词: naringin  furan  oxidative damage  the liver and kidney damage  protective effects
基金项目:国家自然科学基金项目(31571939,31471666);吉林省科技厅自然科学基金项目(201501011 19JC)
作者单位
袁媛;刘黄友;闫海洋;孙冶 吉林大学食品科学与工程学院长春130062长春市九台区鸡鸣山中心学校长春130500 
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中文摘要:
      呋喃是食品热加工过程中产生的对人体有害的典型食品污染物。本研究以呋喃为对象,探讨食源性柚皮苷的抗氧化性及其对呋喃毒性的影响。50只雄性BALB/C小鼠随机分为5组,即对照组、呋喃染毒组(16 mg/kg/d)、柚皮苷保护组(5,10,20 mg/kg/d),通过评价小鼠体内细胞活性氧(ROS)含量、氧化损伤、细胞因子水平、DNA损伤及肝肾损伤情况,结合食源性柚皮苷的体外抗氧化活性研究柚皮苷对呋喃所致毒性的保护作用。结果表明:呋喃染毒对小鼠的肾脏和肝脏造成不同程度的损伤,与呋喃染毒组相比,一方面,柚皮苷通过提升 GST、GSH以及SOD活性,降低MPO和MDA含量减轻呋喃所致小鼠的氧化损伤;另一方面,柚皮苷能降低细胞因子IL-1β、IL-6、IL-10和TNF-α的含量;同时,柚皮苷可以降低ROS,DNA损伤指标8-OHdG,肝损伤指标AST,肾损伤指标ALT、LDH、BUN和肌酐含量。结论:食源性柚皮苷作为抗氧化剂对呋喃所致小鼠肝肾损伤具有一定的保护作用,其中10 mg/kg/d柚皮苷保护组的保护作用最好。
英文摘要:
      Furan, a typical food contaminant generated during the heating of foods, is harmful to the health. In this study, we discussed the antioxidant activity of naringin and its effects on furan-induced toxicity. Fifty male Balb/c mice were randomly divided into five groups(control group, furan-treated group and three naringin-treated groups with the concentration of 5, 10, 20 mg/kg/d, respectively). Protective effects of naringin on furan-induced toxicity were evaluated by determining the ROS content, oxidative damage, cytokine levels, DNA damage, and the liver and kidney damage in a mouse model. The results showed that furan induced the kidney and liver of mice different degrees of damage. Compared with the furan-treated group, naringin mitigated the oxidative damage induced by furan by increasing GST, GSH and SOD activities but decreasing MPO and MDA content. On the other hand, naringin could decrease cytokine levels of IL-1β, IL-6, IL-10 and TNF-α in the serum of furan treated mice. At the same time, naringin could decrease the ROS content, 8-OHdG, the liver and kidney damage indexes of AST, ALT, LDH, BUN and creatinine. Conclusion: naringin, as a kind of antioxidant, has a certain protective effects on the liver and kidney injury of the mice induced by furan, while 10 mg/kg/d of naringin-treated group was the most obviously concentration on furan induced toxicity.
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