双蛋白营养干预促进肠-肝-脾轴免疫互作
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农业农村部中国农业科学院“院级统筹”双蛋白重大项目(Y2018YJ08);首都食品质量安全保障专项(Z191100009318015)


Dual Protein Nutritional Intervention Promotes Immune Interaction of Intestine-Liver-Spleen Axis
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    摘要:

    异基因造血干细胞移植及愈后都与免疫系统密切相关。目前研究显示,除了脾、胸腺、骨髓等免疫器官外,小肠、肝脏等组织器官同样在免疫调控中起着重要作用。对肠-肝轴、肝-脾轴等器官在免疫调控上的互作研究,为人们更好地了解疾病发生机制以及研发免疫相关疗法奠定了基础。作者团队前期将双蛋白应用于异基因造血干细胞移植临床营养干预,发现双蛋白能够显著促进免疫重建,缩短平均移植时间,并对其作用机制进行初探。本文综述肝脏、脾脏、小肠参与机体免疫调控及器官间免疫互作研究进展,提出机体存在“肠-肝-脾轴(ILS Axis)”的免疫互作新概念。同时结合当前临床试验和基础研究,分析双蛋白通过调节肠-肝-脾轴促进免疫重建的潜在机制。

    Abstract:

    The process and recovery of allogeneic hematopoietic stem cell transplantation are closely related to the immune system. Current research shows that in addition to the immune organs such as the spleen, thymus, and bone marrow, tissues such as the small intestine and liver also play an important role in immune regulation. The interaction of the intestine-liver axis, liver-spleen axis and other organs in immune regulation supports a better view to understand the mechanism of disease development and to develop immune related therapy methods. Our team applied the dual-protein to the clinical nutrition intervention of allogeneic hematopoietic stem cell transplantation, and found that the dual-protein can significantly promote immune reconstruction, shorten the average transplantation time, and conduct a preliminary exploration of its mechanism. In this paper, a review about the immune interaction mechanism among intestine, liver and spleen is performed, which followed by a new concept of intestine-liver-spleen axis (ILS Axis) and its mechanism. A hypothesis is proposed that dual-protein promotes hematopoietic and immune reconstruction, and therefore accelerates patient recovery via intestine-liver-spleen axis based on the results of dual-protein clinical trials and animal experiments.

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王靖;张婧婕;韩迪;闫文杰;朱宏;韩娟;梁克红;仇菊.双蛋白营养干预促进肠-肝-脾轴免疫互作[J].中国食品学报,2020,20(9):1-9

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  • 在线发布日期: 2020-10-13
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