牛磺酸对CUMS致抑郁小鼠的干预作用
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国家重点研发计划重点专项(2018YFD0901004);河北省食品科学与工程学科“双一流”建设资金项目(2016SPGCA18)


Intervention of Taurine on CUMS - Induced Depression in Mice
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    摘要:

    通过建立慢性温和不可预知应激(CUMS)模型,研究牛磺酸对抑郁症模型动物的干预作用。试验共设6组:阴性对照组、模型对照组、氟西汀对照组和牛磺酸低、中、高剂量组(0.5,1,2 g/kg bw)。通过对小鼠采用CUMS,建立慢性抑郁动物模型,测定其行为学指标,研究牛磺酸对CUMS致抑郁的干预效果。通过分析血清和脑组织中相关生化指标,研究牛磺酸对CUMS抑郁的干预机制。结果表明,牛磺酸在1和2 g/kg bw剂量条件下可显著改善抑郁小鼠的抑郁样行为;升高CUMS致抑郁小鼠脑组织中多巴胺、五羟色胺和去甲肾上腺素含量,降低单胺氧化酶活性,升高甲状腺素、三碘甲状腺原氨酸和脑源性神经营养因子含量,降低皮质醇、促肾上腺皮质激素、促肾上腺皮质激素释放因子和促甲状腺激素水平。提示:牛磺酸对CUMS诱导的慢性抑郁具有一定干预作用,机制可能与参与调节下丘脑-垂体-肾上腺轴有关。

    Abstract:

    By establishing chronic unpredictable mild stress (CUMS) model, the intervention effect of taurine on depression model animals was studied and the mechanism of action was preliminarily discussed. There were 6 groups: negative control group, model control group, fluoxetine control group and taurine low-dose, medium-dose and high-dose groups (0.5, 1, 2 g/kg·bw). CUMS was used in mice to establish an animal model of chronic depression, and the intervention effect of taurine on depression induced by CUMS was studied by measuring its behavioral indicators. By analyzing the biochemical indexes in serum and brain tissue, the intervention mechanism of taurine on CUMS depression was preliminarily studied. The results showed that taurine at 1 and 2 g/kg·bw could significantly improve the depression-like behavior of depressed mice. Elevated CUMS depression mice brain dopamine, serotonin and norepinephrine levels, reduce the monoamine oxidase activity, increased thyroxin, three iodine thyroid original content of glycine and brain derived neurotrophic factor, reduce cortisol and adrenocorticotropic hormone, corticotrophin releasing factor and thyroid-stimulating hormone levels. It is suggested that taurine has a certain intervention effect on chronic depression induced by CUMS, and the mechanism may be related to the involvement in the regulation of the hypothalamic-pituitary-adrenal axis.

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张晓富;闫晨静;周茜;袁静;韩雪;吴梦颖;王颉;赵文.牛磺酸对CUMS致抑郁小鼠的干预作用[J].中国食品学报,2021,21(6):123-130

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  • 在线发布日期: 2021-07-16
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