植物乳杆菌Zhang-LL及其培养上清液对酒精损伤干预效果评价
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北京市教委科研计划一般面上项目(KM20201 0020002)


Evaluation of Intervention Effect of Lactobacillus plantarum Zhang-LL and Its Culture Supernatant on the Body Injury Induced by Alcohol
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    摘要:

    世界酒文化盛行,酒精对人体的伤害问题日益严峻。益生菌对酒精损伤的干预效果需针对菌株进行评价。在试验周期内,对ICR小鼠灌胃50%乙醇,并分组给予植物乳杆菌Zhang-LL(低剂量组1.0×107 CFU/d,高剂量组1.0×109 CFU/d)及其培养上清液进行干预,干预12周后评价植物乳杆菌Zhang-LL在长期摄入酒精对机体负面影响方面的缓解作用。研究结果显示:植物乳杆菌Zhang-LL干预可显著缓解长期酒精摄入带来的摄食量减少及体重增长抑制(P<0.05);与模型组相比,植物乳杆菌Zhang-LL培养上清液可显著降低酒精损伤小鼠血清中甘油三酯及低密度脂蛋白胆固醇的水平,增加肝脏组织谷胱甘肽的含量,降低其肠道通透性,保持其小肠绒毛的完整性,平衡其肠道菌群结构(P<0.05)。在试验周期内,酒精损伤小鼠肝脏组织结构并未出现病理性改变,组织及血液中谷氨酸氨基转移酶酶活、天门冬氨酸氨基转移酶酶活,组织中丙二醛含量及谷胱甘肽过氧化物酶酶活均没有显著变化,植物乳杆菌各干预组对这些指标也没有显著影响(P>0.05)。结论:植物乳杆菌Zhang-LL对酒精摄入给机体带来的部分负面影响有显著的改善作用,其培养上清液作用效果最为显著。

    Abstract:

    The world wine culture prevails, and the problem of the alcohol injury to people is more and more serious. The intervention effect of diffierent probiotic strains on alcohol injury need to be evaluated. During the experiment period, ICR mice were given 50% ethanol by intragastric gavage, and were divided into groups with Lactobacillus plantalum Zhang-LL (1.0×107 CFU/d in low-dose group, 1.0×109 CFU/d in high-dose group) and its culture supernatant to intervention. After 12 weeks of intervention, the alleviating effect of Lactobacillus plantalum Zhang-LL on the negative effects of long-term alcohol intake and body weight was evaluated. The results showed as follows: Lactobacillus plantalum Zhang-LL intervention could significantly alleviate the reducing of food intake and inhibited weight addtion(P<0.05);Compared with the model group, the supernatant of Lactobacillus plantarii Zhang-LL significantly reduced the levels of triglyceride and low density lipoprotein cholesterol in serum, increased the content of glutathione in liver, decreased intestinal permeability, maintained the integrity of small intestinal villi, and balanced the structure of intestinal microflora in mice with alcohol injury(P<0.05). In the test cycle, the pathological changes of liver tissue structure were not observed in alcohol injury mice. There were no significant changes in glutamate aminotransferase activity, aspartate aminotransferase activity, malondialdehyde content and glutathione peroxidase activity in tissue and blood, and there were no significant changes in these indexes in Lactobacillus plantoflora intervention groups(P>0.05). Conclusions: Lactobacillus plantarium Zhang-LL can significantly improve some of the negative effects caused by alcohol intake, and its culture supernatant has the most significant effect.

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马京升;张红星;谢远红;金君华.植物乳杆菌Zhang-LL及其培养上清液对酒精损伤干预效果评价[J].中国食品学报,2021,21(6):150-158

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  • 在线发布日期: 2021-07-16
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