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副干酪乳杆菌L9缓解抑郁大鼠腹泻的作用机制
陈善斌;邢寒竹;王然;任发政;王希璠
作者单位
陈善斌;邢寒竹;王然;任发政;王希璠 中国农业大学食品科学与营养工程学院齐鲁工业大学(山东省科学院)食品科学与工程学院中国农业大学营养与健康系 
摘要:
腹泻是抑郁症患者常见的顽固性症状。益生菌对一般腹泻有调节作用,而对抑郁患者的腹泻是否有调节作用尚不明确。本文通过慢性温和应激诱导建立大鼠抑郁腹泻模型,研究副干酪乳杆菌L9对抑郁大鼠腹泻的缓解作用。结果表明,相比于对照组,应激后大鼠糖水偏好度降低,强迫游泳不动时间延长,旷场试验中央区域的活动减少,表现抑郁行为;同时排便粒数增多,粪便干量及水分含量增加,全肠传输时间缩短,表现出腹泻症状。用L9干预后,排便粒数、粪便干量、粪便水分含量以及全肠传输时间均恢复到对照组水平。抑郁且腹泻大鼠结肠5-羟色胺4(5-HT4)受体mRNA表达水平异常升高,用L9干预能够恢复其5-HT4受体的mRNA表达水平。
关键词:  抑郁  应激  腹泻  副干酪乳杆菌L9  5-HT4受体
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基金项目:
Action of Lactobacillus paracasei L9 in Alleviating Diarrhea in Depressed Rat
Abstract:
Diarrhea is one of the common refractory symptoms in patients with depression. Probiotics are effective in alleviating common diarrhea, but the effect of probiotics on diarrhea in depressed patients remains unclear. In this study, the effect of Lactobacillus paracasei L9(L9) on diarrhea in rats with depression was investigated by using a rat model induced by chronic mild stress (CMS). The results showed that, compared with the control group, CMS rats showed lower sucrose preference, more immobility in force swimming test and less activity in center zone of open field test. Meanwhile, the number of stool pallets, dry weight and water content of stool were increased, and the transit time of the whole gut was shortened in CMS rats. These results indicated CMS induced depressive-like behavior which accompanied by diarrhea-like symptoms in rats. L9 administration significantly decreased the number of stool pallets, dry weight, and water content of stool, and increased the whole gut transit time in depressed rats with diarrhea. Furthermore, it was found that the mRNA level of 5-HT4 receptors in the colon of depression and diarrhea rats was abnormally increased. After intervention by L9, the transcription level of 5-HT4 receptors was significantly reduced.
Key words:  depression  stress  diarrhea  Lactobacillus paracasei L9  5-HT4 receptor

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