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牡蛎肽和紫苏籽肽及其复配物对环磷酰胺致雄性大鼠性功能损伤的改善作用
李明亮;姜放;魏颖;张瑞雪;张海欣;蔡木易;谷瑞增1,2,3
1.中国食品发酵工业研究院;2.北京市蛋白功能肽工程技术研究中心;3.华狐生物科技(中国)有限公司
摘要:
目的:通过血清激素水平、肾脏和睾丸脏器指数、肾脏和睾丸氧化应激状态以及组织结构变化评价牡蛎肽和紫苏籽肽以及二者复配对大鼠性功能损伤的改善作用。方法:制备牡蛎肽和紫苏籽肽,检测二者的氨基酸组成及相对分子质量;大鼠腹腔注射环磷酰胺建立性功能损伤模型,通过灌胃不同剂量的肽及复配组评价大鼠肾脏和睾丸指数,检测大鼠血清相关指标,肾脏和睾丸氧化应激状态和组织结构变化,分析肽对模型大鼠上述指标的影响。结果:牡蛎肽和紫苏籽肽及复配组都可不同程度地提高大鼠血清相关指标和脏器指数,改善肾脏和睾丸氧化应激状态,调节病理形态。结论:牡蛎肽和紫苏籽肽以及复配组都对大鼠性功能有一定的改善和调节作用,复配组的综合作用效果优于单一肽干预组。
关键词:  牡蛎肽  紫苏籽肽  睾酮  促性腺激素  性功能
DOI:
分类号:
基金项目:“十三五”国家重点研发计划项目(2016YFD 0400604)
Ameliorating Effect of Oyster Peptide, Perilla Seed Peptide and Its Complex Compound for Sexual Function Damage in Male Rats Induced by Cyclophosphamide
Abstract:
Objective: To evaluate the improvement effect of oyster peptide and perilla seed peptide and their combination on sexual function damage in rats through the changes of serum hormone levels, kidney and testis organ index, oxidative stress state and tissue structure changes of kidney and testis. Methods: Preparation of oyster peptide and perilla seed peptide, the amino acid composition and relative molecular mass of the two were detected; rats were injected intraperitoneally with cyclophosphamide to establish a model of sexual function injury, and different doses of peptides and compounding were used to evaluate rat kidneys and testis index, to detect rat serum related indexes, oxidative stress state and tissue structure changes of kidney and testis, and analyze the effect of peptides on the above indexes of model rats. Results: Oyster peptide, perilla seed peptide and compound group can increase the serum index and organ index of model rats to varying degrees, improve the oxidative stress state of kidney and testis and regulate the pathological morphology. Conclusion: Oyster peptide and perilla seed peptide and the compound pair have a certain improvement and regulation effect on the sexual function of rats, the compound effect of the two is better than the single peptide intervention group.
Key words:  oyster peptide  perilla seed peptide  testosterone  gonadotropin  sexual function

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