天然抗菌肽的分子结构与功能特性研究进展
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天津市企业科技特派员项目(18JCTPJC54000);天津市自然科学基金重点项目(18JCZDJC34100)


Research Progress on Molecular Structure and Functional Characteristics of Natural Antimicrobial Peptides
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    摘要:

    抗菌肽来源广泛,抑菌谱广,选择杀伤性强,作用速度快,在临床、医药、禽畜养殖、水产养殖和食品等行业都有良好的应用前景。然而,如今仍面临两大难题:一是与抗生素相比抑菌活力较弱,二是溶血活性和稳定性难以调控。需要人们对天然抗菌肽进行人工改造,从而获得高效、稳定、安全的抗菌肽产品。本文简述了抗菌肽的结构与功能关系,重点阐述影响抗菌肽活性的主要调控因素,如正电荷数、疏水性、两亲性、螺旋度、特殊氨基酸等。为对抗菌肽结构进行针对性设计改造提供了新思路。

    Abstract:

    Antimicrobial peptides, widely distributed in nature, are characteristics of broad antimicrobial spectrum, strong and selective killing ability and fast speed of action. They have potential application prospects in the fields of clinical study, pharmaceuticals industry, livestock breeding, aquaculture and food industries. However, antimicrobial peptides have two drawbacks hampering their applications. First, the antimicrobial activity is relatively weak compared with antibiotics; second, the hemolytic activity and stability are difficult to be regulated. In order to obtain efficient, stable and safe antimicrobial peptides, structural modification of antimicrobial peptides is necessary. In this paper, the relationship between the structure and function of antimicrobial peptides was briefly introduced, and the regulatory factors influencing the activity of antimicrobial peptides, such as the positive charge, hydrophobicity, amphipathy, helicity and special amino acids were mainly elaborated, which provides effective ideas for targeted designing of natural antibacterial peptides.

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孟德梅;刘庆艳;郭雅君;樊振川;杨瑞;生吉萍;.天然抗菌肽的分子结构与功能特性研究进展[J].中国食品学报,2019,19(10):342-350

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  • 在线发布日期: 2019-11-21
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