Aspergillus fungi often invade peanuts， soybeans， corn and other fat-rich crop seeds to produce a variety of mycotoxins， which causing nephrotoxic， hepatotoxic， genotoxic， immunotoxic， teratogenic， and carcinogenic to human and animal. This threaten to human’s food safety and health. Quorum sensing is a mechanism of signal exchange between microbes that depends on population density. Microbes monitor population density and regulate certain physiological activities by sensing changes in the concentration of specific small molecule chemicals（known as signal molecules）. It also found in Aspergillus fungi that quorum sensing can regulate mycelial growth， spore production and toxin biosynthesis and other physiological behavior. This paper reviews the factors involving in the mechanism of quorum sensing in Aspergillus fungi， including signaling molecules （mainly oxylipins）， G protein coupled signaling pathways， and oxidative stress， aiming at providing a reference for the study of the biosynthesis mechanism of the secondary metabolites of Aspergillus fungi and the genetic improvement of host resistance.