In this study， the turbidimetry and viable count methods were used to study the growth of Lactobacillus rhamnosus AS 1.2466T / Lactobacillus bulgaricus ATCC 11842 in basic medium / Jerusalem artichoke juice base medium with different amounts of xylo-oligosaccharides， oligosaccharides， red ginseng liquid and its acid hydrolyzate. The results showed that the enrichment effect of different additives on Lactobacillus rhamnosus AS 1.2466T is red ginseng liquid medicine> red ginseng acid hydrolyzate> xylo-oligosaccharide> oligofructose. The OD600 value of Lactobacillus rhamnosus AS 1.2466T was 1.172 when the amount of red ginseng was 12.50%； and the number of viable cells was 2.72 × 108 CFU / mL， which was an order of magnitude higher than that of the basic medium 7.75 × 107 CFU / mL. The enrichment effect of prebiotics on Lactobacillus bulgaricus ATCC 11842 is red ginseng liquid medicine> xylo-oligosaccharides> red ginseng acid hydrolyzate> oligofructose. The OD600 value of Lactobacillus bulgaricus ATCC 11842 was 0.627 when the amount of red chemical solution was 6.25%； and the number of viable cells was 4.43 × 108 CFU / mL， which was an order of magnitude higher than the maximum viable count of 1.48 × 107 CFU / mL in the basal medium of Jerusalem artichoke. In summary， we found that red ginseng has a better enrichment effect than xylo-oligosaccharides or oligofructose. It can be used as a prebiotics to further study its prebiotics function， which can provide a basis on the study of the effect of red ginseng on intestinal microbes.