Objective： To explore the anti-obesity effect of Monascus-fermented Radix Puerariae extracts（MRPE） on high-fat induced obese C57BL/6J mice. Method. Thirty-two C57BL/6J mice were fed with high-fat diet to induce obesity. Then， the 32 obese mice were irrigated with distilled water （HF group， n = 8）， Monacolin K （MK group， n = 8）， normal dose of MRPE （MRPE-C group， n = 8）， and high dose of MRPE（MRPE-H group， n = 8）， respectively. After 4 weeks， the body weights， body lengths， abdominal fat， body-fat ratio and Lee’s index were recorded. Moreover， serum total cholesterol， triglyceride， HDL， LDL and serum lipopolysaccharide （LBP） were also measured. Results Compared with HF group， the body weight， body-fat ratio， Lee’s index， the serum contents of TC， TG and LBP of the mice from both MRPE-C group and MRPE-H group were reduced （P<0.05）. The serum HDL-C levels were also increased by MRPE treatment （P<0.05）. Moreover， high dose of MRPE treatment could significantly reduce the serum LDL-C level of mice （P<0.05）. In general， a dose-dependent anti-obesity effect of MRPE was observed. Compared with MRPE-C group， body-fat ratio and serum LDL-C level of the mice treated with high dose of MRPE were reduced by 20.43% and 8.22%， respectively. In addition， the anti-obesity and lipid profile modification effect of high dose of MRPE was similar to Monacolin K. Conclusion MRPE can alleviate fat accumulation and reduce body weights of high-fat induced obese mice effectively， which indicated the anti-obesity effect of MRPE.