Objective: To investigate the effect of abalone muscle protein on the nutritional status of mice with chemotherapy tumors. Methods: The Lewis lung cancer chemotherapy mouse model was constructed， and provided nutritional support by giving abalone muscle protein to body weight， tumor volume， organ index (spleen index and thymus index)， and serum. The levels of protein factors ALB， PA and Hb are used as indicators， and the numerical changes of related indicators before and after nutritional support are compared. Results: The mice had obvious lumps after subcutaneous injection 7 days； the survival status showed that the cisplatin chemotherapy mass concentrations of 0.02 mg/mL and 0.04 mg/mL had no mortality. Considering the survival period， 0.02 mg/mL was selected as the optimal concentration of chemotherapeutics. During the nutritional support process， the tumors of the sample in the dose group were significantly reduced， and the tumor inhibition rate reached 20.7%. Compared with the blank group， the sample high-dose group can increase the spleen index and thymus index of chemotherapy mice (P>0.05). Nutritional index results showed that after nutritional support for chemotherapy mice， comparison with blank group (NT)， the ALB and PA of each group were significantly increased， and the PA of the sample low-dose group was significantly increased (P<0.05)， the Hb was significantly reduced (P<0.05). Conclusion: AMPP has a certain effect on improving the nutritional status of mice with tumor chemotherapy.