姜黄素体内吸收代谢及与肠道菌群互作研究进展
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(1.华南农业大学食品学院 广州 510642;2.广东省功能食品活性物重点实验室 广州 510642)

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广东省引进创新创业团队项目(2019ZT08N291)


Research Progresses on the Absorption, Metabolism in Vivo and Gut Microbiota Intervention of Curcumin
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(1.College of Food Science, South China Agricultural University, Guangzhou 510642;2.Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, Guangzhou 510642)

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    摘要:

    姜黄素是一种二苯基庚烷类化合物,因多样而显著的健康效应而被广泛关注。然而,姜黄素经口服消化吸收后生物利用度极低,其健康效应产生的物质基础和过程机制一直备受争议。本文综述姜黄素在机体内吸收转运及代谢过程的研究进展。姜黄素经由上消化道吸收并参与代谢时主要发生还原和结合反应,生成四氢姜黄素、六氢姜黄素、姜黄素葡萄糖苷酸、硫酸化姜黄素等特征代谢物。近年来,姜黄素在下消化道的代谢途径成为研究的热点。姜黄素不仅可被肠道菌群代谢为高活性代谢产物(如阿魏酸、四氢姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素等),也可调节肠道菌群结构,维持菌群稳态。姜黄素的吸收和代谢过程及其与肠道菌群之间的相互作用,是揭示姜黄素健康效应和低生物利用度之间矛盾的关键。

    Abstract:

    Curcumin is a kind of diphenylheptane compound, which has been widely studied because of its evidenced health benefiting effects. However, due to the poor bioavailability of curcumin after digestion and absorption, the mechanisms underlying its bioefficacy have been controversial. This paper reviewd the research progress on the absorption, transportation and metabolism of curcumin in vivo. Curcumin mainly experiences the reduction and conjugation reactions when absorbed through the upper gastrointestinal tract and participates in metabolic pathways where characteristic metabolites such as tetrahydrocurcumin, hexahydrocurcumin, curcumin glucuronide, sulfated curcumin are produced. Its metabolic process in the lower gastrointestinal tract has become the research hotspot in recent years. Curcumin can not only be metabolized into highly active metabolites by gut microbiota, but can also regulate the profile of gut microbiota and maintain the homeostasis of gut microbiota. The absorption and metabolism of curcumin and its bidirectional interaction with the gut microbiota are critical in unveiling the contradiction between the health effect of curcumin and its low bioavailability.

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王浩楠,邱哲瀚,田文妮,肖杰.姜黄素体内吸收代谢及与肠道菌群互作研究进展[J].中国食品学报,2023,23(2):353-364

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  • 收稿日期:2022-02-02
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  • 在线发布日期: 2023-03-22
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