To investigate the effect of lingonberry anthocyanins liposomes on the antioxidant function of Caco-2 cells under oxidative stress. Methods: A mixture of soy lecithin and cholesterol was used to prepare lingonberry anthocyanins liposomes by the thin film dispersion method and to evaluate their stability. A model of hydrogen peroxide-induced oxidative damage in Caco-2 cells was established to evaluate the protective effect of lingonberry anthocyanins liposomes on oxidatively damaged cells. Results: The lingonberry anthocyanin liposomes showed a smooth surface spherical structure with an average particle size of (213.2 ± 13.4)nm and a polydispersity index (PDI) of 0.201 ± 0.026. The particle size and pH of anthocyanins liposomes increased gradually after a period of time with the increase of storage time. At the concentration of 200 μg/mL， the survival rate of oxidatively damaged cells was 74.33% and 84.17% in the anthocyanins group and anthocyanins liposomes group， respectively； the content of ROS in oxidatively damaged cells decreased by 36.58% and 38.02%， respectively； the content of MDA decreased by 43.44% and 53.66%， respectively； the content of T-AOC increased by 3.42 and 8.89 times， respectively. SOD enzyme activity increased by 5.76%， 8.79%； CAT enzyme activity increased by 9.21%， 12.26%， respectively. Conclusion: Liposomes as carriers improve the biological activity of lingonberry anthocyanins， and lingonberry anthocyanins liposomes can reduce the levels of MDA and ROS in damaged cells， improve the survival rate of oxidatively damaged cells and enhance the activity of endogenous antioxidant enzymes and thus play an antioxidant role.