Calcium β-hydroxy-β-methylbutyrate (CaHMB)， as a new food raw material， has obtained approval in multiple countries， including China. In China， CaHMB is allowed to be used in foods for special medical purposes. However， despite being approved in China for over a decade， no products containing CaHMB have been introduced as foods for special medical purposes to the market. Thus， there is a need to form a consensus on the health benefits， safety， dosage and other aspects of CaHMB to facilitate its application in the relevant food industry， regulatory authorities and consumer understanding， thereby advancing its application to better address the nutritional and health needs of the publication. This article provided comprehensive analysis of the global research and application of CaHMB， engaging relevant academic and industrial experts to form the scientific consensus on the application of CaHMB via literature analysis and scientific discussions， as: 1) CaHMB， as new food raw material and the calcium salt form of HMB， plays a crucial role to supplement HMB in promoting muscle protein synthesis and reducing muscle protein breakdown； 2) CaHMB supplementation is beneficial to correct the negative nitrogen balance and improving muscle health in the elderly and people with various diseases (such as sarcopenia syndrome， oncology， etc.)； 3) The safety of CaHMB is widely recognized， and appropriate increase its maximal daily intake limit locally can better support target population to receive health benefits and promote industrial application development. Recommendations: At the policy level， proactive measures can guide the appropriate increase in the maximal daily intake limit of CaHMB to better address the nutritional and health needs of the population； further strengthen scientific research and innovation on CaHMB to provide scientific and technical evidence supporting its optimal application and related policy development； promote CaHMB application in food industry， especially in foods for special medical purposes， to further forest high-quality development of related industries.