薏苡仁油自纳米乳化体系的建立及体外释放
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国家自然科学基金项目(31760459,31960455)


Preparation and in Vitro Release of Self-nanoemulsifying Delivery System of Coix Seed Oil
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    摘要:

    利用伪三元相图及星点设计-效应面优化等方法构建薏苡仁油自纳米乳化体系(CSO-SNEDS),对其进行特性表征和体外释放研究。试验结果显示:该体系最优配方为Tween60/Span20/丙三醇/薏苡仁油,其中薏苡仁油质量分数为16.11%,复合表面活性剂(Tween60/Span20质量比=9 ∶ 1)与助表面活性剂(丙三醇)的比例为3.54。CSO-SNEDS外观为黄色澄清的液体,经稀释可形成均一稳定的纳米乳,平均粒径、多分散指数、ζ-电位分别为47.52 nm,0.188和-15.7 mV。CSO-SNEDS在人工胃液和人工肠液中的体外释放动力学均符合Ritger-Peppas方程,拟合系数分别为0.731和0.912,释放机制为Fick扩散。

    Abstract:

    In this paper, a pseudo-ternary phase diagram and star point design-response surface optimization were used to prepare the coix seed oil self-nanoemulsifying delivery system(CSO-SNEDS), and the characterization and in vitro release studies of CSO-SNEDS were investigated. The results show that the optimal component of the formula is Tween60 / Span20 / glycerol / coix seed oil. Among them, the coix seed oil mass fraction was 16.11%, and the ratio of the composite surfactant(Tween60 / Span20=9∶1) to cosurfactant(glycerol) is 3.54. The CSO-SNEDS is a clear, transparent liquid that appears yellow. After dilution, it can form a uniform and stable nanoemulsion. The average particle size, polydispersity index, and ζ-potential are 47.52 nm, 0.188, -15.7 mV, respectively. The in vitro release kinetics of CSO-SNEDS in artificial gastric fluid and artificial intestinal fluid complies with the Ritger-Peppas equation with fitting coefficients of 0.731 and 0.912, respectively. Both release mechanisms are consistent with Fickian diffusion.

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易醒;李娟;易孜成;罗俊溢;袁弋婷;夏小华;肖小年.薏苡仁油自纳米乳化体系的建立及体外释放[J].中国食品学报,2021,21(6):11-18

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  • 在线发布日期: 2021-07-16
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