A high liquid chromatography-tandem mass spectrometry method with solid phase extraction was established for the determination of bisphenol A，bisphenol F and bisphenol S in milk. The samples were ultrasonically extracted with ammonia and acetonitrile (1 ∶ 9， V/V)， purified by PRiME HLB solid phase extraction column， and separated on an Agilent Poroshell 120 PFP column (100 mm×4.6 mm， 2.7 μm). Bisphenol A， bisphenol F and bisphenol S were detected in a multiple reaction monitoring mode， and quantified by the external standard method. Under the optimized conditions， the limits of quantification of bisphenol A， bisphenol F and bisphenol S in milk were all 2.0 μg/kg. Method recovery was at the range of 90.4%-103.1% and the relative standard deviations from 2.76%-7.34% (n=6). This method had good accuracy and reproducibility， and was suitable for the detection of bisphenol A， bisphenol F and bisphenol S residues in milk.