Objective: Arctium lappa L. root is a edible food and medicinal material， the purpose of this study was to investigate the effect of burdock root on liver-protecting， lipid-lowering and regulating hepatogenic dysglycemia in simplicity obesity rats. Methods: In this study， the model of simplicity obesity rats was established， intervention treatment by gavage of Arctium lappa L. root powder was carried out. The body weight， food intake， blood biochemical indicators， fat weight and lipid levels in the liver such as TG， CHOL were detected， and the pathological changes of the liver and pancreas were detected by HE staining and oil red O staining. Results: After the 4th week of gavage with Arctium lappa L. root， the intervention group significantly inhibited the weight gain of the obesity rats(P<0.05). The levels of TG， TCHO， LDL-C， GLU， NEFA were lower than those of the model rats (P<0.05)； the intervention of Arctium lappa L. root can significantly reduce the lipid droplet deposition in the liver of obesity rats， and the contents of TG and CHOL in the liver were decreased (P < 0.05)， the liver damage of the obese rats was alleviated； the pancreas pathological section results of the Arctium lappa L. intervention group showed that the morphology was ameliorated to the level of the control group， and it could inhibit the increase of hepatogenic blood glucose in the obese rats(P < 0.05). Conclusion: Arctium lappa L. root has an inhibitory effect on the body weight of obesity rats， ameliorate s liver steatosis， reduces liver damage and can effectively regulate the hepatogenic dysglycemia.