Four common antioxidant methods and molecular docking were used to study the antioxidant activity of naringin dihydrochalcone， the whitening activity of naringin dihydrochalcone was studied by measuring the activity of tyrosinase and the cytotoxicity of naringin dihydrochalcone was determined by MTT assay. The conclusion was that naringin dihydrochalcone had better antioxidant and whitening activity. The safe concentration of naringin dihydrochalcone in mice melanoma B16 cells was less than 500 mol/L.