Type 2 diabetes is a metabolic disease characterized by hyperglycemia and disorder of glucose and lipid metabolism. In recent years， studies have found that some amino acids can be used as potential biomarkers of diabetes， such as branched-chain amino acids （BCAAs） and aromatic amino acids （AAAs） which can induce insulin resistance through the mammalian target of rapamycin complex 1 （mTORC1） signal pathway or by middle toxic metabolites accumulation. With the development of metabolomics research， it has been found that the different metabolites between type 2 diabetic animals and diabetic control animals tend to be enriched in amino acid metabolism pathways after polysaccharide intervention， but the specific mechanism is still unclear. Therefore， the mechanism analysis of polysaccharides improving diabetes by regulating amino acid metabolism may explore new strategies for the treatment of this disease.