Obesity is one of the most serious global health problems. Regardless of obesity has an adverse impact on human somatotype and mentality， it can increase the risk of other different chronic diseases， such as cardiovascular disease， diabetes mellitus type II and hypertension. A growing number of scientific studies and epidemiological surveys show that flavonoids are a large class of nature polyphenols without side effect and have the actual activity of fat-lowering and weight-losing. In this paper， based on the latest research， related obesity characteristics， relationship of obesity and chronic inflammation， structure and source of flavonoids， metabolism kinetics and molecular mechanisms of the anti-obesity had been discussed. The research and development suggestion of weight-losing products main containing dietary flavonoids was also put forward， in order to offer a diet of precise dietary interventions for an increasingly large number of overweight and obese groups.