鼠李糖乳杆菌DHC32对小鼠肠道菌群和肠道黏膜免疫的影响
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山西省科技重大专项(201703D211001-06-05);山西省重点研发计划项目(201903D221037)


Effect of Lactobacillus rhamnosus DHC32 on Intestinal Microflora and Mucosal Immune of Mice
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    摘要:

    本文主要研究了鼠李糖乳杆菌 DHC32对正常小鼠肠道菌群和肠道黏膜免疫的影响。结果表明,DHC32降低了粪便中氨、水分及pH值,提高了小鼠粪便菌群营养代谢率。与对照组相比,DHC32处理组小鼠粪便中乳杆菌、双歧杆菌等有益菌的数量显著提高,而拟杆菌、肠杆菌等有害菌的数量显著下降,并且短链脂肪酸的含量大幅提高。本文还证明鼠李糖乳杆菌DHC32通过提高My D88、IL-23及IL-22等免疫因子和抗菌蛋白RegIIIγ,黏附蛋白MUC1、MUC2基因的表达,来稳固黏膜屏障功能,增强宿主的免疫机能而改善动物的肠道健康。

    Abstract:

    This paper mainly studied the effect of Lactobacillus rhamnosus DHC32 on intestinal microflora and mucosal immune of normal mice. The results showed that DHC32 reduced the moisture, ammonia and pH of feces, and increased metabolic capacity of fecal microflora in mice. Compared to the control group, the growth of Lactobacilli and Bifidobacteria were promoted, meanwhile, the Bacteroides fragilis, Enterobacteria and other harmful facal bacteria were inhibited. The production of short chain fatty acids in feces from mice feed on DHC32 strains were significantly promoted. Moreover, DHC32 significantly increased mRNA levels of My D88, IL-23, IL-22 and other intestinal immunoregulatory cytokines. Also, the effect of DHC32 on gene expression of intestinal MUC1, MUC2 and RegIIIγ were studied. These results furtherly demonstrate that Lactobacillus rhamnosus DHC32 efficiently stabilize mucous membrane barrier, and strengthens the host immune function to improve animal intestinal health.

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许 女;魏莎莎;杨 光;陈旭峰;张 浩;王如福.鼠李糖乳杆菌DHC32对小鼠肠道菌群和肠道黏膜免疫的影响[J].中国食品学报,2020,20(6):73-80

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  • 在线发布日期: 2020-07-07
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