魔芋葡甘低聚糖对肥胖大鼠高脂血症及肝损伤的调节作用
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国家重点研发计划项目(2016YFD0400401-2,2016YFD0400104-4)


Modulation Effects of Konjac Glucomannan Oligosaccharides on Hyperlipidemia and Liver Injury in Obese Rats
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    摘要:

    目的:研究魔芋葡甘低聚糖(KOS)对肥胖大鼠高脂血症及肝损伤的调节作用。方法:通过高脂饮食诱导建立肥胖模型。建模成功后,分为正常对照组(NC)、高脂组(MC)和魔芋葡甘低聚糖干预组(KOS),分别进食基础、高脂和干预饲料(5% KOS替代高脂饲料中的基础饲料)。持续干预6周,观察比较大鼠体重、脂质代谢、氧化应激及肝功能指标的变化。结果:与MC组相比,KOS干预后大鼠体重显著下降,血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、丙二醛(MDA)、谷丙转氨酶(ALT)(P<0.01)和谷草转氨酶(AST)(P<0.05)水平显著降低,超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)水平(P<0.01)显著升高,肝重和肝脏指数降低,肝组织学观察显示肝脏损伤减小。碱性磷酸酶(AKP)和高密度脂蛋白胆固醇(HDL-C)水平分别呈下降和升高趋势。结论:KOS可减轻肥胖大鼠体重,有效改善脂质代谢紊乱,提高氧化应激能力,减轻高脂血症症状,对抗肥胖引起的肝脏损伤。

    Abstract:

    Objective: To study the regulative function and mechanism of konjac glucomannan oligosaccharides (KOS) on hyperlipidemia and liver injury in obesity model rats. Methods: A rat model of nutritional obesity was established by high fat diet induction. The rats were divided into three groups: normal control group (NC), high fat model group (MC) and konjac glucomannan oligosaccharides administration group (KOS) after the model established. They were fed basic diet, high fat diet and intervention diet respectively. After administration for 6 consecutive weeks, the changes of body weight, lipid metabolism, oxidative stress and liver function indexs in obese rats were investigated and compared. Results: After 8 weeks feeding of high-fat diet, the obesity model was considered to be built when the weight of the rats fed with a high fat diet exceeded 20% of the average weight of rats fed with a basic diet. Compared with the MC, the levels of TG, TC, LDL-C, MDA, ALT (P<0.01) and AST (P<0.05) were significantly decreased. In contrast, the levels of serum SOD and GSH-Px were significantly increased(P<0.01). Meanwhile, the liver weight and index was reduced. Liver histology showed the decrease of liver injury. Besides, with the model control group, the body weight of obese rats reduced after the administration of KOS. The levels of serum the levels of AKP had an decreasing tendency, and the level of HDL-C had an increasing tendency. Conclusions: KOS administration can lighten the weight of obese rats, ameliorate the lipid metabolism disorder effectively, improve the ability of oxidative stress, alleviate the symptoms of hyperlipidemia, and resist the liver injury caused by obesity.

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李浩霞;周中凯;商文婷;庄 敏;赵亚丽.魔芋葡甘低聚糖对肥胖大鼠高脂血症及肝损伤的调节作用[J].中国食品学报,2020,20(6):81-87

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  • 在线发布日期: 2020-07-07
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