Inonotus obliquus （Fr.） pilat is a kind of health food， with strong anti-oxidative capacity. In order to research anti-oxidative capacity of Inonotus obliquus and its channel tropism， SOD activity， total antioxidant capacity and redox potential of the water extract powder of Inonotus obliquus were studied. 30 subjects were recruited and randomized into 1 of 2 groups. They drank Inonotus obliquus soup or enhanced SOD Inonotus obliquus soup 100 mL each day during 24 days. The change of electric potential difference of 24 acupuncture meridians were analyzed. The results showed that： the water extract powder of Inonotus obliquus has strong anti-oxidative capacity； Inonotus obliquus increased the electric potential difference of Heart Meridian， Pericardium Meridian and Lung Meridian； enhanced SOD Inonotus obliquus further increased the electric potential difference of Spleen Meridian， Bladder Meridian and Liver Meridian， that conformed to the reported effects of Inonotus obliquus.