Acrylamide（AA）， a hazardous substance， was classified AA as group 2A carcinogen， and common in fried and baked foods. At present， most studies focus on how to reduce production of AA in the processing， and it may be another new idea to reduce its harm after its production. The aim of this paper is to explore the protective effect of CCA against AA-induced oxidative in zebrafish embryos. Survival rates， reactive oxygen species （ROS） and malondialdehyde（MDA）， antioxidant enzymes including catalase （CAT）， superoxide dismutase （SOD）， glutathione peroxidase （GSH-Px） and the mRNA expression levels were determined. Results revealed that AA exposure led to oxidative stress characterized by significant increase in ROS and MDA （P＜0.05）. However， compared with AA group， CCA improved the survival rates and the activities of antioxidant enzymes while decreased MDA and ROS levels caused by AA（P＜0.05）. In conclusion， CCA can protect zebrafish embryos from AA-induced oxidative stress.