To isolate and purify the iridoids with antioxidant activity from ethanol extract of the Cornus officinalis， macroporous resin， normal phase silica gel， low pressure normal phase silican gel and cyanopropyl silica， Sephadex LH-20 and preparative HPLC column chromatography were used. The structures of the compounds were identified on the basis of spectral methods including NMR， MS and comparison with literature. The all compounds were evaluated the antioxidant activity using FRAP method and four iridoids with antioxidant activity were identified as loganin （1）， ketologanin （2）， 1-β-O-methyl loganin aglucone （3） and 1-deoxyloganin aglycone （4）. Compounds 3 and 4 were new natural products and reported in this species for the first time.