负载生育酚的玉米醇溶蛋白纳米颗粒的构建及性质表征
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国家自然科学基金项目(31771898,31501407)


Construction and Characterization of Zein Nanoparticles Loaded with Tocopherol
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    摘要:

    采用反溶剂法制备负载生育酚(TOC)的玉米醇溶蛋白(zein)-阿拉伯胶的复合纳米颗粒。探究不同zein ∶ AG比例,不同搅拌速度对zein-AG纳米颗粒稳定性的影响;不同pH值,不同盐离子浓度对负载TOC的zein-AG纳米颗粒稳定性的影响。试验结果表明:当zein ∶ AG质量比1 ∶ 1.5,搅拌速度800 r/min时所得纳米颗粒稳定性较好,粒径125.4 nm,多分散指数(PDI)0.19,电位-32.8 mV;当pH=3~9,盐离子浓度小于20 mmol/L时,zein-AG纳米颗粒相对稳定,表明zein和AG可有效结合,产生电荷屏蔽效应以抵御一定浓度的盐离子;负载TOC的zein纳米颗粒在结合AG后的稳定性显著提高,比负载TOC前对DPPH、ABTS和超氧阴离子都有更高的清除能力;zein/AG-TOC纳米颗粒能够在胃肠道模拟试验中实现缓释。

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    In this paper, zein-arabic gum (AG) nanoparticles loaded with tocopherol (TOC) were prepared by antisolvent method. The effects of different zein ∶ AG ratios and the stirring speeds on the stability of zein-AG nanoparticles were investigated, and the effects of different pH and the different concentrations of salt were also investigated. The experimental results showed that the nanoparticles with zein ∶ GA ratio of 1 ∶ 1.5 and the stirring speed of 200 r/min were stable, and the particle size was 125.4 nm, the polydispersity index (PDI) was 0.19 and the zeta-potential was -32.8 mV. When the pH=3~9, and the concentration of salt ion was less than 20 mmol/L, the zein-AG nanoparticles were stable which proved that zein and AG were bound effectively and had a certain charge shielding effect. The stability of zein-AG nanoparticles loaded with TOC was significantly improved, and the removal capacity of DPPH, ABTS and superoxide anions were higher than that of zein-AG nanoparticles. Moreover, zein/AG-TOC nanoparticles could achieve slow-release in gastrointestinal simulation experiments.

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许雪儿;李娟;陈正行.负载生育酚的玉米醇溶蛋白纳米颗粒的构建及性质表征[J].中国食品学报,2020,20(12):24-30

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  • 在线发布日期: 2021-01-12
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