This paper mainly studied the adsorption characteristics of lead-tolerant E. hirae Qaa of lactic acid bacteria that has been isolated and identified. E. hirae Qaa strains was used in the lead adsorption experiments which were conducted to investigate the effects of factors pH， adsorption temperature， adsorption time， cell mass concentration and lead initial ion mass concentration on lead adsorption efficiency. The optimal adsorption condition of E. hirae Qaa strains was explored by response surface method. The optimal adsorption conditions of E. hirae Qaa adsorption lead were obtained with 8.24 mg/g at adsorption time was 230 min， wet cell mass concentration was 6 g/L， Pb2+ mass concentration was 80 mg/L， pH value was 5.6.