To investigate the effects of chlorophyll on related inflammatory markers in obese mice， so as to explore the biological activity of chlorophyll. Chlorophyll was administered to the obese mice to measure blood sugar， body weight， food intake and other indicators while feeding the high-fat feed. Serum inflammatory factors（TNF-α， IL-6， LEP） and serum endotoxin （ET） were measured by ELISA to analyze the effect of chlorophyll on inflammatory factors in obese mice. The results showed that chlorophyll can significantly reduce inflammatory factors and ET level（P<0.05）， and promote the increase of adiponectin level， which has effects on obesity-related inflammation.