Coenzyme Q10 is a natural bioactive compound, which has strong antioxidant properties. It also can improve immunity and prevent cardiovascular diseases. However, poor water-soluble and unstable physicochemical properties, as well as low bioavailability of coenzyme Q10 greatly limit its application in functional food. The delivery carriers of coenzyme Q10 based on natural materials using nanotechnology could solve the aforementioned problems effectively. The domestic and overseas research reports of coenzyme Q10 vehicles in recent years were comprehensive reviewed, and the prospects for their applications in functional food were focused in the paper.