The continuous dynamic extraction system was used for the dynamic extraction of allicin from the processing wastewater of garlic chips. The raw material processing wastewater of garlic chips and solvent for vegetable oils extraction were used as extraction solvent. Box-Behnken experimental design and response surface（RSM） analysis method were based on the single factor experiments， and the response surface graph and contour map were plotted with the yield and extraction rate of allicin as response value， and the two regression equations for dynamic extraction of allicin were established. The effects of continuous cycle times， organic solvent volume fraction and continuous injection rate on the yield and extraction rate of allicin were investigated. It was found that the continuous cycle times had the greatest effect on the yield and the extraction rate of allicin， then was the organic solvent volume fraction and the continuous injection rate had the least effect. The joint extraction method which used to determine the optimal extraction parameters of allicin were continuous cycle times 4， the organic solvent volume fraction 50%， and the continuous injection rate 4 cm/s. Under this condition， the yield of allicin was 75.098 mg/L. The extraction rate of allicin was 87.450%.