甜菊糖苷改善根皮素溶解性及体外释放的研究
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国家自然科学基金项目(31760459,31960455)


Improving of Solubilization and in Vitro Release Enhancement of Phloretin by Steviol Glycosides
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    摘要:

    为了提高根皮素(PT)在水中的溶解性,利用甜菊糖苷(STE)可自组装形成胶束的特点,建立甜菊糖苷-根皮素胶束增溶体系(STE-PT MC)。通过体外模拟释放试验,对PT增溶前、后的释放度及释放动力学进行研究。结果表明,STE对PT产生良好的增溶效果,在最佳工艺条件下,1.03 g STE可将30 mg PT完全溶解于10 mL水中。STE-PT MC呈平均粒径为5.26 nm的圆球状外形,且STE和PT之间无化学反应发生。STE将PT在人工肠液和胃液中的释放度提高至原来的3~7倍,且增溶前、后的PT在两种介质中的释放动力学发生明显变化。本文建立的STE-PT MC增溶体系所用工艺简单,不添加其它成分,在食品工业上具有较好的实用性。

    Abstract:

    In order to improve the aqueous solubility of phloretin (PT) in aqueous, steviol glycosides (STE), which can self-assemble to form micelles, was used to prepare steviol glycosides-phloretin micellar(STE-PT MC) complex. At the same time, in vitro release and kinetics of PT alone and PT from STE-PT MC were also investigated. The results showed that STE exhibited significant solubility enhancement on PT and 1.03 g of STE can completely dissolve 30 mg of PT in 10 mL of water under the optimum preparation conditions. STE-PT MC was spherical with an average droplet size of 5.26 nm and without any chemical reaction taken place between STE and PT. In vitro release amounts of PT from STE-PT MC in simulate intestinal fluid and stimulate gastric fluid were 3 to 7 times of that of PT alone. In addition, in vitro release kinetics of PT alone and PT from STE-PT MC were significantly different. The STE-PT MC without any other ingredients addition has a simple preparation process and good practicability in food industry.

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肖小年;王凡;周洁;罗俊溢;李娟;易醒.甜菊糖苷改善根皮素溶解性及体外释放的研究[J].中国食品学报,2021,21(3):11-21

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  • 在线发布日期: 2021-04-19
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