By establishing chronic unpredictable mild stress （CUMS） model， the intervention effect of taurine on depression model animals was studied and the mechanism of action was preliminarily discussed. There were 6 groups： negative control group， model control group， fluoxetine control group and taurine low-dose， medium-dose and high-dose groups （0.5， 1， 2 g/kg·bw）. CUMS was used in mice to establish an animal model of chronic depression， and the intervention effect of taurine on depression induced by CUMS was studied by measuring its behavioral indicators. By analyzing the biochemical indexes in serum and brain tissue， the intervention mechanism of taurine on CUMS depression was preliminarily studied. The results showed that taurine at 1 and 2 g/kg·bw could significantly improve the depression-like behavior of depressed mice. Elevated CUMS depression mice brain dopamine， serotonin and norepinephrine levels， reduce the monoamine oxidase activity， increased thyroxin， three iodine thyroid original content of glycine and brain derived neurotrophic factor， reduce cortisol and adrenocorticotropic hormone， corticotrophin releasing factor and thyroid-stimulating hormone levels. It is suggested that taurine has a certain intervention effect on chronic depression induced by CUMS， and the mechanism may be related to the involvement in the regulation of the hypothalamic-pituitary-adrenal axis.