Protein，as the material bassis of life， plays an important role in metabolism and internal environment balance of human. However， some functional properties of naturally derived proteins or those extracted by some methods do not meet the actual processing requirements， so the modification of protein is often required. Ultrasonic has been widely used in the extraction and modification of proteins due to its unique physicochemical effects. Therefore， in the paper， the physicochemical effects of ultrasonic are reviewed， and the research progress of the influence of ultrasonic on the structural and functional properties of the enzyme and proteins are also introduced. Furthermore， the modification effects of the synergistic effects of ultrasonic with other methods on protein are also briefly summarized. This paper can give a reference to future research on mechanism of ultrasonic modification of proteins and the application in protein modification.