In this experiment， C57BL/6 male mice were used to study the effects of grape polyphenol complex on blood lipid reduction based on the changes in body weight and blood lipids in the condition of high-fat diet. The 16S RNA analysis was used to explore the gut microbiota. It was found that grape pomace polyphenols extracts （GPE） and grape seed polyphenols extracts （GSE） could significantly inhibit the weight gain of high-fat diet C57BL/6J mice. GPE gavage for 8 weeks could significantly reduce LDL-c level， while GSE could significantly reduce TG， TC， LDL-c levels. Thus， GPE and GSE could improve lipid disorders in high-fat diet mice and showed a certain effect of lowering blood lipid. Therefore， the intake of GPE and GSE is important for the prevention of hyperlipidemia. Besides， in this experiment， gut microbiota sequencing was used to explain the functional mechanism of grape polyphenol complex， and the effects of intestinal microbes and polyphenols on blood lipids were analyzed. It was found that the gut microbiota affected lipid metabolism and participated in the adjustment of GPE and GSE on blood lipids levels.