功能调和油改善大鼠血压、组织脂肪酸和氧化-还原稳态的研究
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Studies of Functional Blended Oil in Improving Blood Pressure, Tissue Lipids and Redox State in Rats
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    摘要:

    目的:以猪油(LO)和大豆油(SO)作为对比,评估一款功能调和油(BO)在不同能量水平下对大鼠血压、组织脂肪酸和氧化-还原稳态的影响。方法:将90周Wistar大鼠分成3个组,分别饲喂LO、SO、BO 12周,每组再划分低、中、高3个能量组(脂肪供能6.7%,10.9%,48.1%),测量大鼠血压、组织脂肪酸和抗氧化等指标。结果:在高脂日粮条件下,与LO组和SO组相比,BO可显著降低大鼠体重、脂肪质量和体脂比率;显著提高血浆、肝脏和脂肪组织中α-亚油酸/亚油酸比值(ALA/LA),降低血浆甘油三酯(TG)水平,使大鼠维持较好的收缩压、舒张压和平均压。此外,BO可显著提高大鼠血浆和心脏总抗氧化(T-AOC)和谷胱甘肽过氧化物酶(GSH-PX)活性,降低活性氧(ROS)和丙二醛(MDA)水平。结论:功能调和油具有降低肥胖大鼠体脂比率,改善血脂血压的功效,相关作用机制可能与其含有适宜比例的ALA/LA和多种油脂功能成分有关。

    Abstract:

    Objective: Lard oil (LO) and soybean oil (SO) were compared to evaluate the effects of a functional blend oil(BO) on the blood pressure, tissue lipids and redox state in rats at different energy levels. Methods: Ninety male Wistar rats were divided into three groups and fed for 12 weeks with LO, SO and BO. Each group was divided into low, middle and high fat groups and fed with oil supply ratios of 6.7%, 10.9% and 48.1%, and the blood pressure index, tissue lipids index and redox index were detected. Results: Under high-fat diets, BO could significantly reduce rats body weight, fat weight, and body fat ratio; significantly increase plasma, liver, and adipose tissue ALA / LA ratios, reduce plasma TG levels, and keep rats more stable. Systolic, diastolic and mean pressure. In addition, BO can significantly increase T-AOC and GSH-PX activity in rats' plasma and heart, reduce ROS and MDA levels. Conclusion: Functional blend oil has the effect of reducing the body fat ratio and improving blood lipid and blood pressure in obese rats, and the mechanism may be related to its content of ALA / LA and a variety of lipid functional components.

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杨绍军;刘昌树;王赛;丛洋;吕一品;唐雪;周鹏.功能调和油改善大鼠血压、组织脂肪酸和氧化-还原稳态的研究[J].中国食品学报,2021,21(7):130-140

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  • 在线发布日期: 2021-08-12
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