Using natural taurine as experimental material， the intervention effect of taurine on two acute depression animal models by establishing two acute depression animal models. ICR mice were used as experimental animals. Low taurine （0.5 g/kg bw）， medium taurine （1 g/kg bw） and high taurine （2 g/kg bw） dose groups were set. At the same time， solvent control group， model control group and positive （fluoxetine） control group were set. The intervention effect of natural taurine on behavioral despair mice was investigated by establishing behavioral despair animal model. The intervention mechanism of taurine on reserpine induced acute depression was analyzed through behavioral， biochemical indexes in serum and brain tissue. The results showed that taurine medium and high dose groups could significantly improve the depression-like behavior of behavioral despair mice. And ease of the mice induced by reserpine drooping eyelids， and higher depression in mice brain serotonin， norepinephrine and dopamine levels， reduce the monoamine oxidase activity， higher content of brain derived neurotrophic factor， reduce corticotrophin releasing factor， adrenocorticotropic hormone， cortisol levels， improve related biochemical indicators. It is showed that taurine can interfere with depression in both behavioral depression model and reserpine induced depression model， and the mechanism may be related to the increase of monoamine neurotransmitters and the regulation of adrenal dysfunction.