Purpose： To investigate the protective effects of Wickerhamomyces anomalus QF-1-1 against lead toxicity in rats. Methods： Rats were randomly divided into low and high dose lead-poisoning model group， low and high dose of intervention group， blank control group. The lead-poisoning model group were given 1 mg/mL and 4 mg/mL lead acetate water for free drink and were fed normal diet while the intervention group were given 1 mg/mL and 4 mg/mL lead acetate water for free drink and were fed a diet containing Wickerhamomyces anomalus QF-1-1 powder， the control group were given distilled water for free drink and were fed normal diet. The experiment lasted for 7 weeks， during which the lead content in the feces of each group was measured regularly. After 7 week of feeding， the body mass， organ indexes， lead content in the blood， liver， kidney， brain of rats were tested. Paraffin sections of liver， kidney and brain tissue were prepared for observation of histopathological changes by hematoxylin and eosin staining. Results： After 7 weeks of feeding， the lead-poisoning model was constructed successfully， low dose lead-poisoning model group reached moderate lead poisoning， high dose lead-poisoning model group reached severe lead poisoning， and significant pathological tissue damage occurred in liver， kidney and brain. Compared with the model group， the liver and kidney indexes， lead content in the blood， liver， kidney， brain were decreased and lead content in the feces of intervention group were increased significantly. Moreover， the pathological changes of liver， kidney and brain tissues were improved. Conclusions： Wickerhamomyces anomalus QF-1-1 can alleviate damages to body caused by Pb， especially for moderate lead poisoning.