Objective： This work was to explore the repaired position of dietary fiber on lipid metabolism shifts caused by gut microbiome dysbiosis. Methods： We built the animal model for the study with gut microbiome dysbiosis administrated by i.g. with CRO and intervened by inulin. Gut microbiome was analyzed by high throughput sequencing and bioinformatics analyses of bacteria. The composition of fatty acids and short chain fatty acids（SCFAs） were determined by gas chromatography. Blood lipids and bile acids were assayed by kit and UPLC-MS/MS， respectively. Results： Inulin improved the profiles of gut microbiome and repaired the lipids metabolism shifts from gut microbiome dysbiosis. SCFAs were remarkably high after treatment by inulin. Besides， inulin regulated fatty acids metabolism and partially repaired bile acid profiles. Conclusion： It was recommended that inulin repaired lipid metabolism shifts from gut microbiome dysbiosis via bile acids-FXR pathway.