Obesity is associated with an increasing tendency which is a typical metabolic syndrome resulting from metabolic disorders due to the excessive food intake， and thus leading to a citical threat to human health. Studies were proved that food reward was an important factor affecting feeding behavior and played a key role in the occurrence and development of obesity. Recent studies indicated that brain-gut peptide， leptin， insulin and gut microflora could directly or indirectly regulate appetite and stabilize body weight through dialogue between intestine and brain， which mediated a crucial role in preventing obesity. Therefore， this review highlighted the role of the dialogue between intestine and brain in food reward and expanded strategies for the prevention and treatment of obesity.