: High-sugar and high-fat diet leads to a significant increase in the worldwide incidence of various chronic diseases. The study chose wild type Caenorhabditis elegans N2 as object of study， construct sucrose / stearic acid damage nematode model by adding 100 mmol/L sucrose or 100 μg/mL stearic acid into the medium， then investigated the repair effects of 4 natural active ingredients: piperine， bayogenin， peonidin-3-O-glucoside and pelargonidin-3-O-rutinoside on sucrose / stearic acid damaged nematodes respectively. The results are as follows: 1) As for sucrose damaged nematodes， 500 μg/mL of piperine and 1 000 μg/mL of pelargonidin-3-O-rutinoside have good repair effects， the spawning volume increased by 25% and 4.6%， the body length of nematode on the fourth day increased by 16.84% and 0.98%， and the lifespan increased by 8.1% and 3.19%， respectively. 1 000 μg/mL of peonidin-3-O-glucoside has a good repair effect on reproductive ability and growth as well as development， the total amount of progeny increased by 55.81%， however the life span was decreased by 22.57%. The bayogenin have a significant destructive effect. 2) As for stearic acid damaged nematodes， 500 μg/mL of piperine， 500 μg/mL of bayogenin， and 500 μg/mL of peonidin-3-O-glucoside have repair effects， the total number of progenies increased by 18.41%， 13.41% and 29.17% respectively. The body length of nematode on the third day increased by 6.59%， 3.19% and 10.98% respectively. The life span increased by 15.4%， 2.84% and 10.46% respectively. Pelargonidin-3-O-rutinoside has a good repair effect on reproductive ability and growth as well as development， but does not affect the life span. The above results indicated that piperine， bayogenin， peonidin-3-O-glucoside and pelargonidin-3-O-rutinoside all have repair effects on sucrose / stearic acid damage. This model can be used as a simple and feasible technique to quickly identify the repair effect of natural products on glycolipid damage.