Agricultural products， food and feed are often contaminated by many mycotoxins. The development of high-throughput mycotoxin rapid detection products， which are used to detect multiple toxins is one of the key directions. Among the current mainstream rapid detection products， traditional paper-based sensors with colloidal gold as signal markers are mostly used to detect a single toxin， with limited information and low sensitivity. The multi-toxin paper-based sensor uses multi-toxins to couple multi-antigens， which is lower in cost and time-consuming， but the detection sensitivity is affected by the change of the test sample liquid volume. In recent years， paper-based sensors constructed with advanced materials such as precious metal nanoparticles， quantum dots， carbon nanomaterials， up-conversion particles， lanthanide metal nanoparticles， which can improve the performance of multi-toxin paper-based sensors. And they have gradually become a research for hot spot of rapid detection of multiple mycotoxins. The author summarized the detection principle and composition of multiplexed paper-based sensors， and then reviewed the applications of paper-based sensors based on advanced materials reported in the past years for simultaneous detection of multiple mycotoxins， with a view to rapid and joint detection of multiple mycotoxins.