Granaticin， as a member of benzoisochromanequinones(BIQ)， has the bioactivities of antibacterial， antitumor and antibiofilm. Granaticin shows the light blue color under the alkaline condition and has potential application in functional pigment. Due to the continuous exploration of the bioactivities and medicinal value of granaticin and its analogs， many researchers are interested in studying it. This review concluded the basic characteristics， sources， biosynthesis and bioactivities of granaticin and its analogues， and provided support for the study and application of granaticin A and its analogues.