黑小麦粉对高脂血症大鼠脂代谢的影响
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(1.河北省农林科学院粮油作物研究所 河北省作物遗传育种实验室农业农村部作物基因资源与种质创制河北科学观测实验站 石家庄 050035;2.河北省农林科学院经济作物研究所 石家庄 050051;3.河北医科大学第二医院 石家庄 050000)

作者简介:

兰素缺(1967—),女,学士,研究员

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基金项目:

国家重点研发计划项目(2021YFD1200601);河北省重点研发项目(19226361D);河北省现代农业产业技术体系小麦创新团队项目(21326318D)


Effects of Black Wheat Flour on Lipid Metabolism in Hyperlipidemia Rats
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(1.Institute of Cereal and Oil Crops, Hebei Academy of Agriculture and Forestry Sciences / Hebei Laboratory of Crop Genetics and Breeding / Hebei Research Station of Crop Gene Resource & Germplasm Enhancement,Ministry of Agriculture and Rural Affairs, Shijiazhuang 050035;2.Institute of Cash Crops, Hebei Academy of Agriculture and Forestry Sciences, Shijiazhuang 050051;3.The Second Hospital of Hebei Medical University, Shijiazhuang 050000)

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    摘要:

    目的:探讨黑小麦粉对高脂血症大鼠血脂的调节作用及肝肾功能的影响,为高脂血症的合理饮食奠定基础。方法:50只大鼠按体重随机被分为5组,每组10只。对正常对照组大鼠饲喂标准饲料,其余4组大鼠饲喂高脂饲料诱导血脂异常。高脂血症大鼠分为模型对照组、黑小麦高剂量组、中剂量组和低剂量组。连续饲养6周,检测大鼠血脂、体重等,观察肝脏、肾脏病理切片。结果:1)黑小麦不同剂量组大鼠体重增加均显著低于正常对照组,并且高剂量组显著低于模型对照组。2)黑小麦各组大鼠的血脂水平显著降低,且TC和LDL低于模型对照;不同剂量组间血脂水平无明显差异。3)病理检测表明,与模型对照相比,黑小麦各组肝细胞脂肪变性程度较低,肾组织病变减轻。结论:黑小麦粉能减轻大鼠体重,改善大鼠脂代谢紊乱,减轻高脂血症对肝脏、肾脏损伤。

    Abstract:

    Objective: The purpose of the study was to explore the effects of black wheat flour on hypolipidemic action, liver and kidney function of rat with hyperlipidemia, so as to lay the foundation of a dietary therapy for hyperlipidemia. Methods: A total of 50 rats were randomly divided into five groups according to their body weight, 10 rats in each group. The normal control group rats were fed with a standard diet, whereas the other four groups of rats were fed with a high-fat diet to induce dyslipidemia. Hyperlipidemia rats were randomly divided into dyslipidemia control group (DC) and black wheat flour high dose group, middle dose group and low dose group. Rats were fed with corresponding food for 6 weeks, blood lipid levels and body weight of the rats were detected, and the pathological sections of the liver and kidney tissues were observed. Results: 1) The weight-gain-ratio of all dose groups rats were significantly lower than that of the control group rats, and it was significantly lower in black wheat high dose group when compared to the DC group. 2) Compared with before dietary intervention, the blood lipid levels of rats in the three dose groups were significantly reduced, and TC and LDL were lower than that of the DC group, all dose groups serum levels is no statistically difference. 3) The pathological examination showed that the hepatocyte steatosis was at lower level, and renal lesion was alleviated in black wheat all dose groups, compared to the DC. Conclusions: Black wheat flour can lighten the weight of hyperlipidemia rats, ameliorate the lipid metabolism disorder effectively, alleviate the liver and kidney injury caused by hyperlipidemia.

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兰素缺,孟雅宁,李光威,王绵,张业伦,李杏普.黑小麦粉对高脂血症大鼠脂代谢的影响[J].中国食品学报,2022,22(6):161-167

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  • 收稿日期:2021-06-24
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  • 在线发布日期: 2022-07-19
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