The objective was to investigate the hypoglycemic and hepatoprotective effect of corn silk extract on db/db mice by body weight， fasting blood glucose (FBG)， oral glucose tolerance test (OGTT)， insulin tolerance test (ITT)， liver pathomorphological organ index and histological analysis. In this study， the body weight and FBG of each group of db/db mice were recorded by continuous gavage of corn silk extract for 12 weeks， and OGTT， ITT and liver sections were observed. The results showed that the FBG of db/db mice after gavage with corn silk extract was significantly reduced (P<0.05)， and the OGTT and ITT were significantly improved (P<0.05). At the same time， corn silk extract had some protective and repairing effects on the liver tissues of db/db mice. There was no significant difference in body weight between groups during gavage. In conclusion， the corn silk extract has improved the high blood glucose level and protected the liver in T2DM.