Bioactive peptide which is produced by protein degradation has certain physiological regulation function， and its biological function is reflected in antibacterial， antioxidant， anti-inflammatory， antihypertensive， immune regulation and others. In specially， Anti-inflammatory peptides can participate in the body's inflammatory response by regulating the secretion of cytokines and the synthesis of inflammatory mediator， which would play the physiologically regulatory function. Chronic inflammation is directly related to cardiovascular disease， diabetes and other metabolic diseases. Compared with anti-inflammatory drugs， food derived anti-inflammatory peptides have the characteristics of safety without side effects， which can provide a new strategy for the prevention of inflammation. Therefore， this review focused on the extraction， inflammatory regulation and signal pathways of food derived anti-inflammatory peptides. Hopefully， this review could supply the theory support on the scientific research and the product development of food derived anti-inflammatory peptides.