In order to study the anti-αs1-casein allergy mechanism of EGC and EGCG， BALB/C mice were first sensitized with αs1-casein， and nutritional intervention was given by EGC and EGCG during the challenge stage. The contents of mast cell protease， histamine， specific antibody IgE， cytokine secretion and histopathological observation were used as the main evaluation indexes.The results showed that both EGC and EGCG significantly reduced the levels of mast cell protease， histamine， specific IgE antibodies and Th2 cytokines in allergic mice. Meantime， the results about histopathology showed that EGC and EGCG significantly reduced the degree of the lesions in the intestine， thymus， spleen and lung. The conclusions can provide theoretical basis for the pathway of tea polyphenols to regulate cow milk allergen， and further studies need to be done to explore the mechanism of anti-allergy in terms of signal transduction and gene expression level.