In this study， a meal replacement powder rich in dietary fiber was prepared. The main raw materials were oat-corn-konjac extruded powder and oat bran powder， and the auxiliary ingredients were skim milk powder， whole powder of Pueraria lobata， pumpkin powder， etc. The sensory score and dispersibility index were used as indicators， and the response surface test was optimized on the basis of single-factor experiments. The final optimal process formulation of meal replacement powder was 27% extruded powder， 33% oat bran powder， 20% skim milk powder， and 9% pumpkin powder， and under these conditions， the sensory score of meal replacement powder was 76.78 and the dispersibility index was 99.03%. The total dietary fiber content of the final product was 19.31%， the soluble dietary fiber was 11.42%， and the estimated glycemic index (eGI) was 73.41， which is a medium GI food.