In recent years， the prevalence of intestinal diseases have been rising in many countries， which has seriously affected the quality of life. Many studies have demonstrated that probiotics could promote the prevention and treatment of intestinal diseases， but the safety issues of some probiotics are still a matter of debate. The study had found that the postbiotics (components and/or metabolites of probiotics) have the functions of protecting the epithelial barrier， anti-tumor and immune regulation， which could improve health and prevent or treat intestinal diseases. Compared with those of probiotics， postbiotics have the advantages of clear chemical structure and safe dosage parameters， and could be used as a substitute for probiotics to become a new direction for the treatment of diseases. In this paper， the probiotic effect of metazogens in disease prevention， the biological role and related mechanisms of metazogens in the prevention of inflammatory bowel disease， irritable bowel syndrome and colorectal cancer intestinal diseases were reviewed， which was of great significance for the future application of metazogens in the disease prevention.