Dry-cured ham possesses many bioactive peptides produced from muscle degradation during the whole process. In order to investigate the antihypertensive activity of bioactive peptides in dry-cured ham， Jinhua ham was chosen to isolate the peptides with measuring their renin regulating effect in vitro as well as the blood pressure regulating capacity in vivo. Known from the results， the Jinhua ham peptides had the suppressing effect on renin under the mass concentration of 10 mg/mL with the inhibition rate of 62.21%. In spontaneously hypertensive rats(SHR)， ham derived peptides were gavaged with the measurements of diastolic and systolic blood pressure. In the treatment of 20 mg/mL peptides， diastolic and systolic blood pressure was significantly decreased compared with control， which showed the similar effect with 5 mg/mL of captopril clinical. However， the suppressing effect of Jinhua ham peptides lasted longer than captopril. In summary， the peptides in Jinhua dry-cured ham had significant antihypertensive activity supplying the potential to carry out the further research on the physiological regulation function of bioactive peptides in dry-cured hams.